Top 10 Antidepresants Study

Top 10 Most Popular Antidepressants: How They Measure Up

Researchers used two separate measures to rate the top 10 antideressants. Efficacy was first measured. This is how likely patients were to experience the desired effects of the drug. Acceptability was the second measure. This is how likelihood that a patient would continue using a drug for the duration of the study (it makes sense that a high ratio of patients that stop using a drug, indicates the presence of undesirable side effects).


  1. Mirtazapine (Remeron)
  2. Escitalopram (Lexapro)
  3. Venlafaxine (Effexor)
  4. Sertraline (Zoloft)
  5. Citalopram (Celexa)
  6. Buproprion (Wellbutrin)
  7. Paroxetine (Paxil)
  8. Milnacipran (Savella)
  9. Fluoxetine (Prozac)
  10. Duloxetine (Cymbalta)


  1. Sertraline (Zoloft)
  2. Escitalopram (Lexapro)
  3. Buproprion (Wellbutrin)
  4. Citalopram (Celexa)
  5. Fluoxetine (Prozac)
  6. Milnacipran (Savella)
  7. Mirtazapine (Remeron)
  8. Venlafaxine (Effexor)
  9. Paroxetine (Paxil)
  10. Duloxetine (Cymbalta)

Source: Cipriani et al, "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Lancet (2009).